Lonza and BioWa Sign License Agreements with Pfizer, Inc. Allowing Use of Their POTELLIGENT® CHOK1SV Cell Line for Therapeutic Antibody Research and Development

July 30,2013

Basel Switzerland/ La Jolla CA, 30 July 2013 – BioWa, Inc. and Lonza today announced that they have entered into research agreements with Pfizer Inc. allowing the use of the POTELLIGENT® CHOK1SV Cell Line in the research and development of multiple proprietary antibodies in Pfizer’s pipeline.  

POTELLIGENT® CHOK1SV is a host cell line for manufacturing recombinant antibodies that combines the power of BioWa’s engineered glycosylation POTELLIGENT® Technology with the advantages of Lonza’s industry leading GS Gene Expression System™.  The GS System™ includes Lonza’s pre-eminent host cell line, CHOK1SV.    

“We are pleased that the core value of POTELLIGENT® Technology has been recognized by a global pharmaceutical company such as Pfizer, and are excited to work together with Pfizer on their innovative antibody research pipelines.” said Yasunori Yamaguchi, PhD, President and CEO of BioWa.   

The POTELLIGENT® CHOK1SV Cell Line retains the desirable features of a high-producing cell line (robust, high-yielding, scalable), with the advantage of a proven bioprocess platform for the CHOK1SV Cell Line. Antibodies produced by this cell line exhibit enhanced antibody dependent cellular cytotoxicity (ADCC) and can exert potent cytotoxic effects even when their target antigen is low. In addition, they work in whole blood and retain all other desirable features of common antibodies.  

“The GS System and the CHOK1SV Cell Line continue to be a gold standard for therapeutic antibody development.  We are proud to be able to support Pfizer with this technology for their ongoing development portfolio.” said Karen Fallen, VP Head of Licensing, Lonza Custom Development Services.

The POTELLIGENT® CHOK1SV Cell Line is available to Lonza customers under a license agreement, as part of the cell line construction service offering. For more information on accessing the POTELLIGENT® CHOK1SV Technology, please contact GSLonza@lonza.com.

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