Contract covers the immunogenicity screening of ImmuneMed’s novel investigational therapeutic compound
Lonza will complete the pre-clinical screening followed by deimmunization of ImmuneMed’s lead compound at its development facility in Cambridge, UK
The immunogenicity risk assessment will be performed using Epibase™ v3, Lonza's latest version of their T-cell epitope prediction engine
Basel, Switzerland, 8 December 2011; Lonza announced today an agreement with a South Korean Biotechnology company, ImmuneMed, Inc. for the in silico screening followed by deimmunization of their Virus Suppressing Factor (VSF), under investigation for the treatment of viruses such as the encephalomyocarditus, influenza and hepatitis. Under the agreement, Lonza will perform an immunogenicity risk assessment using their latest version (v.3) of their T-cell epitope prediction engine, Epibase™. This assessment will help reduce ImmuneMed’s attrition rate in their drug development program. The pre-clinical assessment will be performed at Lonza’s protein services and development facility in Cambridge, UK.
Lonza’s Epibase™ v.3 in silico Screening Platform incorporates the most recent experimentally generated binding affinities of peptides to the HLA receptor, as well as the characteristics of the latest 3D structures of HLA receptors. Data obtained from the in silico screening will be used to deimmunize the humanized VSF.
“We are excited to support Korea’s growing biotechnology landscape with our risk assessment services,” said Janet White, Head of Lonza’s Development Services. “This partnership is a direct reflection of Lonza’s commitment to the success of our customers’ pre-clinical pipeline.”
Virus Suppression Factor is a highly active anti-viral protein that has shown superior anti-viral activities exceeding those of known cytokines on the market today. VSF is produced in the body, similar to Interferon, however the broad spectrum of potential treatment of VSF is unprecedented as compared to any single anti-viral agent.
ImmuneMed Inc. is a South Korean biotechnology company whose focus is the development of innovative products for the diagnosis and treatment of infectious diseases. ImmuneMed has discovered a highly active antiviral substance called Virus Suppressing Factor (VSF) that shows increased potent antiviral activity than any other antiviral cytokine. In addition, ImmuneMed is also developing diagnostic kits for the early detection of acute febrile illnesses such as Scrub typhus, Lepospirosis, Hemorrhagic fever with renal syndrome, and Murine typhus. ImmuneMed was founded by its CEO, Dr. Yoon-Won Kim. It has investors such as Macrogen Inc., TAGOS Invest Corp. and Korea Venture Investment Corp.
For further information, please see http://www.immunemed.co.kr
Lonza is one of the world's leading suppliers to the pharmaceutical, healthcare and life science industries. Products and services span its customers’ needs from research to final product manufacture. It is the global leader in the production and support of active pharmaceutical ingredients both chemically as well as biotechnologically. Biopharmaceuticals are one of the key growth drivers of the pharmaceutical and biotechnology industries. Lonza has strong capabilities in large and small molecules, peptides, amino acids and niche bioproducts which play an important role in the development of novel medicines and healthcare products. Lonza is also the world leader in microbial control providing innovative, chemistry-based and related solutions to destroy or to selectively inhibit the growth of harmful microorganisms. Its activities encompass the areas of water treatment, personal care, health and hygiene, industrial preservation, materials protection, and wood treatment. In addition, Lonza is a leader in cell-based research, endotoxin detection and cell therapy manufacturing. Furthermore, the company is a leading provider of value chemical and biotech ingredients to the nutrition and agro markets.
Lonza is headquartered in Basel, Switzerland and is listed on the SIX Swiss Exchange and secondary listed on the Singapore Exchange Securities Trading Limited (“SGX-ST”). Lonza is not subject to the SGX-ST’s continuing listing requirements. Lonza is subject to the listing rules of the SIX Swiss Exchange, which do not have specific requirements equivalent to the listing rules of the SGX-ST in respect of interested person transactions, acquisition and realizations, and delisting. In 2010, the company had sales of CHF 2.680 billion. Further information can be found at www.lonza.com.
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